Lifirafenib maleate
Product Specifications
CAS Number
1854985-74-2
Target
Raf, EGFR
Related Pathways
Tyrosine Kinase/Adaptors, JAK/STAT signaling, MAPK, Angiogenesis
Bioactivity
Lifirafenib (BGB-283) maleate, a novel inhibitor targeting both Raf Kinase and EGFR, exhibits potent activity with IC50 values of 23 nM and 29 nM against recombinant BRaf V600E and EGFR, respectively [1].
Smiles
OC(/C=C\C(O)=O)=O.[H][C@@]12[C@@H](C(NC3=C4)=NC3=CC=C4C(F)(F)F)[C@]1([H])C5=CC(OC6=C7C(NC=C6)=NC(CC7)=O)=CC=C5O2.OC(/C=C\C(O)=O)=O.[H][C@@]89[C@@H](C(NC%10=C%11)=NC%10=CC=C%11C(F)(F)F)[C@]8([H])C%12=CC(OC%13=C%14C(NC=C%13)=NC(CC%14)=O)=CC=C%12O9.OC(/C=C\C(O)=O)=O
Molecular Formula
C62H46F6N8O18
Molecular Weight
1305.06
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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