LY3522348
Product Specifications
CAS Number
2568608-48-8
Target
Others
Related Pathways
Others
Bioactivity
KHK-IN-3 (Example 1), a ketohexokinase (KHK) inhibitor, plays a crucial role in the study of various diseases including kidney disease, nonalcoholic steatohepatitis (NASH), diabetes, and heart failure. KHK, a pivotal rate-limiting enzyme and fructokinase, facilitates the metabolism of fructose by catalyzing the transformation of fructose into fructose-1-phosphate (FIP) utilizing ATP. This process lacks feedback inhibition, leading to the buildup of metabolites involved in lipogenesis, gluconeogenesis, and oxidative phosphorylation [1].
Smiles
C[C@@H]1N(C=2N=C(C=C(C(F)(F)F)N2)C3=CN(CC(=O)N4CCNCC4)N=C3)CC1
Molecular Formula
C18H22F3N7O
Molecular Weight
409.41
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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