JGB-1-155
Product Specifications
CAS Number
3011930-28-9
Target
NAMPT
Related Pathways
Metabolism
Bioactivity
JGB-1-155, serving as a positive allosteric modulator (N-PAMs), effectively enhances the activity of nicotinamide phosphoribosyltransferase (NAMPT) with an EC 50 of 3.29 μM. It mitigates oxidative stress by elevating NAD+ levels in THP-1 human monocytes and reduces TNFα-induced reactive oxygen species (ROS) in HT-22 cells [1].
Smiles
C(CN(C(=O)C1=CC=CO1)CC2=CC=C(N(C)C)C=C2)C3(C(C)C)CC(C)(C)OCC3
Molecular Formula
C26H38N2O3
Molecular Weight
426.59
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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