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PD-168077

PD-168077 is a selective dopamine D4 receptor agonist, with a Ki of 9 nM[1].

Product Specifications

CAS Number

190383-31-4

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/pd-168077.html

Smiles

O=C(NCN1CCN(C2=CC=CC=C2C#N)CC1)C3=CC=CC(C)=C3

Molecular Formula

C20H22N4O

Molecular Weight

334.41

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Clifford JJ, et al. Topographically based search for an "Ethogram" among a series of novel D (4) dopamine receptor agonists and antagonists. Neuropsychopharmacology. 2000 May;22 (5) :538-44.|[2]Gu Z, et al. Activation of dopamine D4 receptors induces synaptic translocation of Ca2+/calmodulin-dependent protein kinase II in cultured prefrontal cortical neurons. Mol Pharmacol. 2006 Mar;69 (3) :813-22.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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