JAK1-IN-13

Product Specifications

CAS Number

2778330-90-6

Target

JAK

Related Pathways

Angiogenesis|||Stem Cells|||JAK/STAT signaling|||Tyrosine Kinase/Adaptors|||Chromatin/Epigenetic

Bioactivity

JAK1-IN-13 (compound 36b) functions as an orally active, potent, and highly selective JAK1 inhibitor, exhibiting an IC 50 of 0.044 nM. It effectively reduces STAT3 phosphorylation [1].

Smiles

N(C1=C2C(=NC=C1C(NC)=O)NC=C2)[C@@H]3C[C@H](C)N(CC4=CC=C(C(F)(F)F)C=C4)CC3

Molecular Formula

C23H26F3N5O

Molecular Weight

445.48

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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