JAK1-IN-13
Product Specifications
CAS Number
2778330-90-6
Target
JAK
Related Pathways
Angiogenesis|||Stem Cells|||JAK/STAT signaling|||Tyrosine Kinase/Adaptors|||Chromatin/Epigenetic
Bioactivity
JAK1-IN-13 (compound 36b) functions as an orally active, potent, and highly selective JAK1 inhibitor, exhibiting an IC 50 of 0.044 nM. It effectively reduces STAT3 phosphorylation [1].
Smiles
N(C1=C2C(=NC=C1C(NC)=O)NC=C2)[C@@H]3C[C@H](C)N(CC4=CC=C(C(F)(F)F)C=C4)CC3
Molecular Formula
C23H26F3N5O
Molecular Weight
445.48
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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