ITF5924
Product Specifications
CAS Number
2760854-72-4
Target
HDAC
Related Pathways
Chromatin/Epigenetic, DNA Damage/DNA Repair
Bioactivity
ITF5924 (compound 1), a potent HDAC6 inhibitor featuring a difluoromethyl-1,3,4-oxadiazole (DFMO) moiety, exhibits an IC 50 of 7.7 nM and surpasses 104-fold selectivity over other HDAC subtypes. As a slow-binding substrate analog of HDAC6, ITF5924 undergoes an enzyme-catalyzed ring opening reaction, resulting in the formation of a stable, long-lasting enzyme-inhibitor complex [1].
Smiles
C(N1C=C(N=N1)C2=CC=C(NC=3NCCN3)C=C2)C4=CC=C(C=C4)C=5OC(C(F)F)=NN5
Molecular Formula
C21H18F2N8O
Molecular Weight
436.42
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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