HSD17B13-IN-23
Product Specifications
CAS Number
2758802-19-4
Target
Dehydrogenase
Related Pathways
Metabolism
Bioactivity
HSD17B13-IN-23 (compound 18) serves as a potent inhibitor of hydroxysteroid 17?-dehydrogenase 13 (HSD17B13), demonstrating inhibition constants (IC 50) of ?0.1 ?M and ?1 ?M when estradiol and Leukotriene B3 act as substrates, respectively. This compound is significant in the management of nonalcoholic fatty liver diseases (NAFLDs), including nonalcoholic steatohepatitis (NASH) [1].
Smiles
C(NCCC(C)(C)C)(=O)C1=C(NC(=O)C2=CC(F)=C(O)C(F)=C2)C=CS1
Molecular Formula
C18H20F2N2O3S
Molecular Weight
382.42
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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