HMC-B17
Product Specifications
CAS Number
2935913-83-8
Target
MAPK
Related Pathways
MAPK
Bioactivity
HMC-B17 is a selective and orally bioavailable HPK1 inhibitor (IC50 = 1.39 nM) that enhances anti-PD-L1 efficacy. It significantly increases IL-2 secretion in Jurkat cells (EC50 = 11.56 nM) and can be utilized for cancer research [1].
Smiles
O(C)C=1C=C(C=2C=3C(NC2)=NC=C(C3)C4=CC=C(C=C4)C5CCN(C)CC5)C=CC1OC
Molecular Formula
C27H29N3O2
Molecular Weight
427.54
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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