HAChE/hBACE-1-IN-4
Product Specifications
CAS Number
229476-71-5
Target
Cholinesterase (ChE), Beta Amyloid
Related Pathways
Neuroscience
Bioactivity
Compound AK-2, also known as hAChE/hBACE-1-IN-4, is a quinazoline derivative that demonstrates significant inhibitory activity against the enzymes hAChE and hBACE-1 (hAChE, IC 50 = 0.283 μM; hBACE-1, IC 50 = 0.231 μM) . This compound also shows potential in inhibiting Aβ aggregation and possesses characteristics such as non-neurotoxicity, blood-brain barrier permeability, and oral activity, making it a valuable agent for research in Alzheimer's disease [1].
Smiles
O(C)C1=CC=2C(=NC=NC2C=C1OC)N3CCN(CC4=CC=CC=C4)CC3
Molecular Formula
C21H24N4O2
Molecular Weight
364.44
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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