GSK_WRN3
Product Specifications
CAS Number
2923009-50-9
Target
Others, DNA/RNA Synthesis
Related Pathways
Others, Cell Cycle/Checkpoint, DNA Damage/DNA Repair
Bioactivity
GSK_WRN3 acts as a selective inhibitor of the WRN protease with an IC 50 of 8.6 μM. It demonstrates significant selectivity by covalently binding to the Cys727 residue of the WRN protein. By inhibiting WRN protease activity, GSK_WRN3 hinders the growth of MSI tumor cells by increasing DNA double-strand breaks and inhibiting cell proliferation [1].
Smiles
OC1=C(NC(=O)C(C(N[C@@H]2C=CS(=O)(=O)C2)=O)=C1)C3CCCCC3
Molecular Formula
C16H20N2O5S
Molecular Weight
352.4
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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