GPR183 antagonist-2
Product Specifications
CAS Number
2924063-98-7
Target
EBI2/GPR183
Related Pathways
GPCR/G Protein
Bioactivity
GPR183 antagonist-2 (compound 32), a selective antagonist of GPR183, exhibits excellent water solubility and pharmacokinetic properties. This compound effectively diminishes paw and joint swelling, and reduces gene expression of pro-inflammatory cytokines (MCP-1, MMPs, and VEGF) in a dose-dependent manner within a collagen-induced arthritis (CIA) mouse model. GPR183 antagonist-2 is applicable in researching autoimmune diseases [1].
Smiles
C(=C/C(=O)N1CCN(C(=O)C=2C=NC(OC)=NC2)CC1)\C=3C=C4C(=CC3)OC(F)(F)O4
Molecular Formula
C20H18F2N4O5
Molecular Weight
432.38
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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