GLPG3312
Product Specifications
CAS Number
2340388-72-7
Target
Bcr-Abl, TGF-beta/Smad, RIP kinase, Src, SIK, LIM Kinase, Discoidin Domain Receptor (DDR), MAPK
Related Pathways
Apoptosis, PI3K/Akt/mTOR signaling, NF-κB, Cell Cycle/Checkpoint, Angiogenesis, Stem Cells, MAPK, Cytoskeletal Signaling, Tyrosine Kinase/Adaptors
Purity
0.9853
Bioactivity
GLPG3312 is a selective and potent pan-SIK inhibitor with the advantage of oral activity, with IC50=0.6-2.0 nM for SIK1, SIK2 and SIK3, and exhibits anti-inflammatory and immunomodulatory activity in both human primary myeloid cells and mouse models.
Smiles
O=C(NC1CC1)C2=C(OC)C=C(C=C2OC(F)F)N3C=NC=4C=C(C=CC43)C=5C=NN(C5)C
Molecular Formula
C23H21F2N5O3
Molecular Weight
453.44
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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