FGFR4-IN-17
Product Specifications
CAS Number
3011805-61-8
Target
FGFR
Related Pathways
Tyrosine Kinase/Adaptors, Angiogenesis
Bioactivity
FGFR4-IN-17 (Compound (S) -23), a piperazinyl diflurindan derivative featuring a pyridinyl group, functions as an inhibitor of FGFR. It exhibits IC 50 values of 24.2 nM for FGFR1, 16.1 nM for FGFR2, 78.0 nM for FGFR3, and 68.0 nM for FGFR4. Notably, FGFR4-IN-17 demonstrates significant antitumor activity [1].
Smiles
FC1(F)C=2C([C@H](C1)N3CCN(C)CC3)=CC=C(NC(=O)C4=CC(C#CC=5C=C(OC)C=NC5)=C(F)C=C4)C2
Molecular Formula
C29H27F3N4O2
Molecular Weight
520.55
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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