Fasudil mesylate
Product Specifications
CAS Number
1001206-62-7
Target
PKA, PKC, Autophagy, Calcium Channel, ROCK
Related Pathways
Cell Cycle/Checkpoint, Stem Cells, Autophagy, Chromatin/Epigenetic, Membrane transporter/Ion channel, Metabolism, Cytoskeletal Signaling, Tyrosine Kinase/Adaptors
Bioactivity
Fasudil mesylate (HA-1077; AT877) is a nonspecific, orally active inhibitor of RhoA/ROCK, exhibiting additional inhibitory effects on protein kinases with a K i of 0.33 μM for ROCK1. It shows IC 50 values of 0.158 μM for ROCK2, and 4.58 μM, 12.30 μM, and 1.650 μM for PKA, PKC, and PKG, respectively. Furthermore, Fasudil mesylate acts as a potent Ca 2+ channel antagonist and vasodilator, enhancing its pharmacological profile [1] [2] [3] [4] [5] [6].
Smiles
S(C)(=O)(=O)O.S(=O)(=O)(C=1C2=C(C=CC1)C=NC=C2)N3CCCNCC3
Molecular Formula
C15H21N3O5S2
Molecular Weight
387.47
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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