Enpp-1-IN-19
Product Specifications
CAS Number
2738583-25-8
Target
PDE, STING
Related Pathways
Metabolism, Immunology/Inflammation
Bioactivity
Enpp-1-IN-19 (compound 29f) is an orally active inhibitor of ENPP1 that effectively blocks cGAMP hydrolysis with an IC50 of 68 nM. It not only enhances anti-PD-L1 responses and curtails tumor growth in CT26 syngeneic models but also boosts STING-mediated type I interferon responses. Additionally, Enpp-1-IN-19 fosters immune memory and aids in preventing tumor recurrence [1].
Smiles
C(C=1C=2C(C(=O)N(C)N1)=CC=CC2)C3=CC=C(NS(N)(=O)=O)C=C3
Molecular Formula
C16H16N4O3S
Molecular Weight
344.39
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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