EGFR-IN-97
Product Specifications
CAS Number
3020681-05-1
Target
EGFR|||Apoptosis
Related Pathways
Apoptosis|||JAK/STAT signaling|||Tyrosine Kinase/Adaptors|||Angiogenesis
Bioactivity
EGFR-IN-97 (compound 6q), an EGFR inhibitor, demonstrates effectiveness in inhibiting Ba/F3-EGFR L858R/T790M/C797S and Ba/F3-EGFR Del19/T790M/C797S cells, exhibiting IC 50 values of 0.42 ?M and 0.41 ?M, respectively. Additionally, at a concentration of 0.8 ?M, EGFR-IN-97 is capable of inducing apoptosis in NCI-H1975-EGFR L858R/T790M/C797S cells [1].
Smiles
[C@@H](C(NC1=CC=C(NC2=NC(N)=NC=C2)C=C1)=O)(N3CC=4C(C3=O)=CC=C(C4)C5=CC=C(C=C5)N6CCN(C)CC6)C7=CC=CC=C7
Molecular Formula
C37H36N8O2
Molecular Weight
624.73
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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