EGFR/HER2-IN-12
Product Specifications
CAS Number
2237230-21-4
Target
EGFR
Related Pathways
Angiogenesis, JAK/STAT signaling, Tyrosine Kinase/Adaptors
Bioactivity
EGFR/HER2-IN-12 (compound 14b) serves as a dual inhibitor targeting EGFR and HER2, demonstrating 81% and 51% inhibition respectively at a concentration of 10 μM. This compound exhibits minimal toxicity towards A431 and MDA-MB-361 cancer cells [1].
Smiles
N(C1=C2C(SC(=C2)C3=CC=C(N(=O)=O)C=C3)=NC=N1)C4=CC(Cl)=C(OC5=CC(C)=CC=C5)C=C4
Molecular Formula
C25H17ClN4O3S
Molecular Weight
488.95
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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