EGFR/AURKB-IN-1
Product Specifications
CAS Number
3008543-34-5
Target
EGFR, Aurora Kinase
Related Pathways
Angiogenesis, JAK/STAT signaling, Cell Cycle/Checkpoint, Tyrosine Kinase/Adaptors, Chromatin/Epigenetic
Bioactivity
EGFR/AURKB-IN-1 (compound 7) serves as a dual inhibitor targeting EGFR/AURKB, effectively inhibiting the phosphorylations of L858R EGFR and AURKB with IC50 values of 0.07 and 1.1, respectively. The compound engages with the hydrophobic region I or the αC-helix out pocket of EGFR and the back pocket of AURKB. This binding action suppresses tumor cell growth, division, and metastasis, making it a valuable agent for cancer research [1].
Smiles
N(C1=C2C(NC(=C2)C=3N(C)N=CC3)=NC=N1)C4=CC=C(OCC5=CC=CC=C5)C=C4
Molecular Formula
C23H20N6O
Molecular Weight
396.44
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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