EGFR T790M/L858R-IN-7
Product Specifications
CAS Number
3032760-90-7
Target
EGFR
Related Pathways
Tyrosine Kinase/Adaptors|||Angiogenesis|||JAK/STAT signaling
Bioactivity
EGFR T790M/L858R-IN-7 (Compound 72), a novel pyrimidine compound, exhibits high efficacy in inhibiting the EGFR T790M and L858R mutations, with a 93% inhibition rate at 0.05 ?M. It achieves its inhibitory action by specifically binding to the kinase domain of EGFR, which prevents phosphorylation activity [1].
Smiles
N(C=1N=C(N2C=3C(C=C2)=CC=CN3)C=CN1)C4=C(OC)C=C(OC)C(NC(/C=C/CN5CCOCC5)=O)=C4
Molecular Formula
C27H29N7O4
Molecular Weight
515.56
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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