EGFR mutant-IN-2
Product Specifications
CAS Number
2770009-06-6
Target
EGFR
Related Pathways
Tyrosine Kinase/Adaptors, JAK/STAT signaling, Angiogenesis
Bioactivity
EGFR mutant-IN-2 (Compound D51) is an inhibitor of EGFR mutants, specifically targeting EGFR L858R/T790M/C797S and EGFR del19/T790M/C797S mutants with IC50 values of 14 nM and 62 nM, respectively. This compound exhibits favorable pharmacokinetic (PK) parameters, safety properties, in vivo stability, and demonstrates antitumor activity [1].
Smiles
C(F)(F)(F)C=1C(C=2C=3C(N(S(CC)(=O)=O)C2)=CC=CC3)=NC(NC=4C=C5C(=CC4)N(CCN(C)C)C=C5)=NC1
Molecular Formula
C27H27F3N6O2S
Molecular Weight
556.6
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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