EGFR kinase inhibitor 4
Product Specifications
CAS Number
2922402-05-7
Target
EGFR
Related Pathways
Tyrosine Kinase/Adaptors, JAK/STAT signaling, Angiogenesis
Bioactivity
EGFR Kinase Inhibitor 4 (Compound 4) acts as a bivalent ATP-allosteric inhibitor targeting EGFR, with a potent inhibitory effect (IC 50: 1.8 nM) on mutant EGFR (LRTMCS) . It is primarily utilized in the study of non-small cell lung cancer (NSCLC) [1].
Smiles
C(C)C=1NC(=C(N1)C2=CC(NC(=O)C3=C4C(NC=5C(C(=O)N4)=CC=CC5)=CC=C3)=CC=C2)C=6C=C(NC7=C(OC)C=CC(NC(C=C)=O)=C7)N=CC6
Molecular Formula
C40H34N8O4
Molecular Weight
690.75
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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