EGFR kinase inhibitor 3
Product Specifications
CAS Number
2922402-03-5
Target
EGFR
Related Pathways
Tyrosine Kinase/Adaptors|||JAK/STAT signaling|||Angiogenesis
Bioactivity
EGFR kinase inhibitor 3 (compound 2) serves as a dual-action inhibitor targeting both ATP and allosteric sites of the EGFR kinase, exhibiting potent IC50 values of less than 10 nM for wild-type EGFR, 1.5 nM for the L858R mutation, 0.059 nM for the L858R/T790M mutation, and 0.064 nM for the L858R/T790M/C797S mutation. It is classified as a C-linked inhibitor [1].
Smiles
S(C)C=1NC(=C(N1)C=2C=C(NC(C)=O)N=CC2)C3=CC(NC(=O)C4=C5C(NC=6C(C(=O)N5)=CC=CC6)=CC=C4)=CC=C3
Molecular Formula
C31H25N7O3S
Molecular Weight
575.64
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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