Divarasib adipate
Product Specifications
CAS Number
2762240-36-6
Target
Kras|||Ras
Related Pathways
MAPK|||GPCR/G Protein
Bioactivity
Divarasib (GDC-6036) adipate is a selective and highly potent KRAS G12C inhibitor with an impressively low IC 50 value of <0.01 ?M, designed for oral administration. It covalently attaches to the switch II (SW-II) pocket in KRAS G12C, irreversibly maintaining the protein in its inactive GDP-bound state [1] [2].
Smiles
C(CCC(O)=O)CC(O)=O.FC=1C2=C(C(=NC(OCC3N(C)CCC3)=N2)N4C(C)CN(C(C=C)=O)CC4)C=C(Cl)C1C5=C(C(F)(F)F)C(C)=CC(N)=N5
Molecular Formula
C35H42ClF4N7O6
Molecular Weight
768.2
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
24132-05061 5x 30 µg
Human Immunoglobulin G (IgG-Fc) AssayLite™ Antibody (APC Conjugate)
Ask
View Details 
MBS1252151-01 0.02 mg (E-Coli)
Recombinant Giardia intestinalis Flavohemoprotein (hmpA)
Ask
View Details MBS1252151-02 0.02 mg (Yeast)
Recombinant Giardia intestinalis Flavohemoprotein (hmpA)
Ask
View Details