Divarasib adipate
Product Specifications
CAS Number
2762240-36-6
Target
Kras|||Ras
Related Pathways
MAPK|||GPCR/G Protein
Bioactivity
Divarasib (GDC-6036) adipate is a selective and highly potent KRAS G12C inhibitor with an impressively low IC 50 value of <0.01 ?M, designed for oral administration. It covalently attaches to the switch II (SW-II) pocket in KRAS G12C, irreversibly maintaining the protein in its inactive GDP-bound state [1] [2].
Smiles
C(CCC(O)=O)CC(O)=O.FC=1C2=C(C(=NC(OCC3N(C)CCC3)=N2)N4C(C)CN(C(C=C)=O)CC4)C=C(Cl)C1C5=C(C(F)(F)F)C(C)=CC(N)=N5
Molecular Formula
C35H42ClF4N7O6
Molecular Weight
768.2
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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