CDK8-IN-14

Product Specifications

CAS Number

2924193-12-2

Target

CDK

Related Pathways

Cell Cycle/Checkpoint

Bioactivity

CDK8-IN-14 (compound 12) effectively inhibits CDK8, demonstrating an IC50 of 39.2 nM, and exhibits potent anti-AML cell proliferation effects, with a GC50 value of 0.02±0.01?M in MOLM-13 cells and 0.03±0.01?M in MV4-11 cells [1].

Smiles

C(N)(=O)C=1C=C(C=2C=C3C(=CNC3=NC2)C=4C=COC4)C=CC1

Molecular Formula

C18H13N3O2

Molecular Weight

303.31

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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