CDDD11-8
Product Specifications
CAS Number
2241659-94-7
Target
FLT, CDK
Related Pathways
Tyrosine Kinase/Adaptors, Cell Cycle/Checkpoint, Angiogenesis
Bioactivity
CDDD11-8 is an orally administered, highly potent and selective CDK9 and FLT3-ITD inhibitor, with K i values of 8 nM and 13 nM, respectively. It effectively reduces the proliferation of leukemia cell lines, showing particular efficacy against those with the FLT3-ITD mutation [1] [2].
Smiles
CC=1C(C=2N3C(=NC2)C=CC(=C3)C4=CC=CC=C4)=NC(N[C@@H]5CC[C@@H](N)CC5)=NC1
Molecular Formula
C24H26N6
Molecular Weight
398.5
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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