C5aR1 antagonist 2
Product Specifications
CAS Number
2365161-92-6
Target
Complement System
Related Pathways
Immunology/Inflammation
Bioactivity
C5aR1 antagonist 2 (Compound 6a), an orally active antagonist of C5a receptor 1 (C5aR1), effectively inhibits increases in neutrophil counts induced by C5a. This compound demonstrates potency in both DISCO and migration assays, with IC50 values of 21 and 3 nM, respectively. It is utilized in the study of acute and chronic inflammatory diseases [1].
Smiles
C(N1C=2C(N(C1=O)C3CCN(CC3)C4=C(C)C=CC=C4C)=CC=CC2OC)C5=C(C(F)(F)F)C=CC=C5
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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