BET-IN-23
Product Specifications
CAS Number
2953287-57-3
Target
Apoptosis, Epigenetic Reader Domain
Related Pathways
Apoptosis, Chromatin/Epigenetic
Bioactivity
BET-IN-23 (Compound 23) is a BD2-selective BET inhibitor with an IC50 of 2.9 nM. It exhibits anticancer activity by significantly inhibiting the proliferation of acute myeloid leukemia (AML) cell lines, inducing G0/G1 arrest, and apoptosis in vitro [1].
Smiles
O(C1=C(C=C(C(C)(C)O)C=C1)C=2C(NCC(=O)N3CCOCC3)=CC(=O)N(C)C2)C4=C(C)C=C(F)C=C4C
Molecular Formula
C29H34FN3O5
Molecular Weight
523.6
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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