ATF4-IN-1
Product Specifications
CAS Number
2991057-76-0
Target
Others|||PERK
Related Pathways
Others|||Apoptosis
Bioactivity
ATF4-IN-1 (Compound 21) serves as an inhibitor of ATF4, demonstrating effective suppression of ATF4 expression in Thapsigargin-stimulated HEK-293T cells with an IC50 of 32.43 nM. Compared to ISRIB, ATF4-IN-1 shows enhanced activity and exhibits minimal cytotoxicity, with an IC50 of 96 ?M in HEK-293T cells. This compound is utilized in the investigation of neurodegenerative diseases [1].
Smiles
ClC=1C=C2C=C(OC2=CC1)C=3OC(=NN3)[C@@H]4CC[C@@H](NC(COC5=CC=C(Cl)C=C5)=O)CC4
Molecular Formula
C24H21Cl2N3O4
Molecular Weight
486.35
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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