Antitumor agent-138
Product Specifications
CAS Number
2975168-22-8
Target
Apoptosis, Microtubule Associated
Related Pathways
Apoptosis, Cytoskeletal Signaling
Bioactivity
Antitumor agent-138 (compound 5b), with an IC 50 of 1.87 μM, inhibits tubulin polymerization at the tubulin colchicine-binding sites. It arrests the cell cycle at the G2/M phase and induces apoptosis in MCF-7 cells. Additionally, this compound suppresses cell migration and angiogenesis [1].
Smiles
O=C(C1=CC(OC)=C(OC)C(OC)=C1)N2N=C(N)C=C2C=3C=CC(=CC3)C
Molecular Formula
C20H21N3O4
Molecular Weight
367.4
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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