AChE-IN-63
Product Specifications
CAS Number
876685-78-8
Target
Beta Amyloid, Beta-Secretase, Cholinesterase (ChE)
Related Pathways
Neuroscience
Bioactivity
AChE-IN-63 (Compound 5AD) serves as a selective inhibitor of hAChE, exhibiting an IC 50 value of 0.103 μM. Moreover, it inhibits hBChE and hBACE-1 with IC 50 values of 10 μM and 1.342 μM, respectively. AChE-IN-63 is effective in inhibiting Aβ aggregation and preventing the formation and deposition of Aβ1-42. It can effectively penetrate the blood-brain barrier and is orally bioavailable. This compound is primarily utilized in research related to Alzheimer's disease [1].
Smiles
N=1N=C(OC1C=2C=CC=CC2)CN3CCN(C4=NC=CC=C4)CC3
Molecular Formula
C18H19N5O
Molecular Weight
321.38
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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