ACBI3
Product Specifications
CAS Number
2938169-76-5
Target
Kras|||Others|||Ras|||PROTACs
Related Pathways
Others|||MAPK|||PROTAC|||GPCR/G Protein
Purity
0.9924
Bioactivity
ACBI3 is a selective pan-KRAS degrader with anticancer activity that degrades oncogenic KRAS. ACBI3 inhibits the growth of most cancer cell lines driven by KRAS mutations.
Smiles
C[C@]1(C2=C(SC(N)=C2C#N)CCC1)C3=NC(=NO3)C4=NC(=NC=C4)N5[C@@H](C)CN(CCCCOC6=CN([C@H](C(=O)N7[C@H](C(N[C@@H](CO)C8=CC=C(C=C8)C=9SC=NC9C)=O)C[C@@H](O)C7)C(C)C)N=N6)CCC5
Molecular Formula
C50H62N14O6S2
Molecular Weight
1019.25
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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