LX7101 hydrochloride
Product Specifications
CAS Number
2319882-48-7
Target
Others|||LIM Kinase|||ROCK|||PKA
Related Pathways
Cell Cycle/Checkpoint|||Tyrosine Kinase/Adaptors|||Others|||Stem Cells|||Cytoskeletal Signaling
Bioactivity
LX7101 is a potent inhibitor of both LIM kinase (LIMK) 1 and 2, and Rho-associated kinase 1 (ROCK1) and ROCK2, with IC50 values of 32, 4.3, 69, and 32 nM, respectively. It is selective, demonstrated by its lack of cross-reactivity in a panel of binding assays involving 78 receptors, transporters, and an additional 430 kinases, at a concentration of 10 ?M. The topical administration of LX7101 (3 ?l of a 1 mg/ml solution) to the eye has been shown to reduce intraocular pressure in a dexamethasone-induced mouse model of glaucoma.
Smiles
CC=1C2=C(N=CN=C2NC1)N3CCC(C(NC4=CC(OC(N(C)C)=O)=CC=C4)=O)(CN)CC3.Cl
Molecular Formula
C23H29N7O3?HCl
Molecular Weight
488
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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