6-hydroxy Bexarotene
Product Specifications
CAS Number
368451-07-4
Target
Others|||Endogenous Metabolite
Related Pathways
Metabolism|||Others
Bioactivity
6-Hydroxy Bexarotene, an oxidative metabolite of bexarotene, serves as a high-affinity ligand for retinoid X receptors (RXRs), specifically binding to RXR?, RXR?, and RXR?, as well as to the retinoic acid receptor ? (RAR?) with dissociation constants (Kds) of 3.46, 4.21, 4.83, and 8.17 ?M, respectively. It demonstrates selective activation of RXR?, RXR?, and RXR? over RAR?, RAR?, and RAR? in vitro, with half-maximal effective concentrations (EC50s) of 398, 356, 420, 4,414, 2,121, and 2,043 nM, respectively.
Smiles
Cc1cc2c(cc1C(=C)c1ccc(cc1)C(O)=O)C(C)(C)CC(O)C2(C)C
Molecular Formula
C24H28O3
Molecular Weight
364.485
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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