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N-Deacetylcolchicine

Product Specifications

CAS Number

3476-50-4

Target

Others, Microtubule Associated

Related Pathways

Others, Cytoskeletal Signaling

Bioactivity

Trimethylcolchicinic acid methyl ether (HAN 76504), an antimitotic agent, blocks microtubule assembly by attaching to tubulin and inhibiting its polymerization. It enhances tubulin's intrinsic GTPase activity, induces apoptosis across various normal and tumor cell lines, and activates the JNK/SAPK pathway. Currently unnamed, it is referred to by a provisional code name in line with MedKoo Chemical Nomenclature (https://www.medkoo.com/page/naming) for ease of communication.

Smiles

O(C)C1=C2C=3C(=CC(=O)C(OC)=CC3)[C@@H](N)CCC2=CC(OC)=C1OC

Molecular Formula

C20H23NO5

Molecular Weight

357.4

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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