What is the catalog number for AF-353 hydrochloride?

The catalog number for AF-353 hydrochloride is T85192.

What sizes are available for AF-353 hydrochloride?

AF-353 hydrochloride is available in the following size(s): 10 mg, 50 mg.

How many pack sizes does AF-353 hydrochloride come in?

AF-353 hydrochloride is available in 2 different pack sizes.

Is AF-353 hydrochloride in stock?

AF-353 hydrochloride is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures AF-353 hydrochloride?

AF-353 hydrochloride is manufactured by Molfinity.

What is the estimated delivery time for AF-353 hydrochloride?

Estimated delivery time for AF-353 hydrochloride is approximately 10 business day(s), depending on your location.

AF-353 hydrochloride

Product Specifications

CAS Number

927887-18-1

Target

Others, P2X Receptor

Related Pathways

Neuroscience, Membrane transporter/Ion channel, Others

Bioactivity

This novel compound is an orally bioavailable antagonist of P2X3/P2X2/3 receptors, exhibiting potent activity with a pIC50 of 8 in both human and rat, and a pIC50 of 7.3 specifically for the human P2X2/3 receptor. It demonstrates high brain penetration, evidenced by a brain to plasma ratio of 6, and effectively blocks agonist-evoked intracellular Ca2+ flux and inward currents within the nanomolar range (10 nM to 1 μM) in cell lines that express human P2X3 and P2X2/3 receptors recombinantly. The compound also shows favorable pharmacokinetic properties, with a half-life (t1/2) of 1.63 hours and a time to reach maximum concentration (Tmax) of 30 minutes.