GSK3368715 hydrochloride
Product Specifications
CAS Number
2227587-25-7
Target
Others, Histone Methyltransferase
Related Pathways
Others, Chromatin/Epigenetic
Bioactivity
GSK3368715, a first-in-class, orally active, potent, and selective SAM-noncompetitive inhibitor of Type I Protein Arginine Methyltransferases (PRMTs), exhibits anti-tumor efficacy across multiple cancer models and alters exon usage with IC50 values in the lower nM range. It synergizes with GSK3326595 (Type II inhibitor) (Axon 3750) to inhibit tumor growth.
Smiles
C(OCC)C1(COCC)CCC(CC1)C=2C(CN(CCNC)C)=CNN2.Cl
Molecular Formula
C20H38N4O2.HCl
Molecular Weight
403
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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