C82
Product Specifications
CAS Number
691862-35-8
Target
Others, PDE
Related Pathways
Metabolism, Others
Bioactivity
C82 acts as an inhibitor of Mycobacterium tuberculosis (Mtb) cyclic dinucleotide phosphodiesterase (CdnP), with an IC50 value of 17.5 μM. This particular enzyme is responsible for breaking down cyclic di-AMP (c-di-AMP) into adenosine 5'-monophosphate (AMP) . Notably, C82 demonstrates selectivity for Mtb CdnP over other bacterial cyclic dinucleotide phosphodiesterases (CDN PDEs) such as Yybt, RocR, and Group B Streptococcus (GBS) CdnP, as well as the mammalian CDN PDE ENPP1, and the viral CDN PDE poxin, showing effectiveness at a concentration of 200 μM.
Smiles
O=C1C2=C(SC(CC)=C2)N=CN1CC(NC3=C(OC)C=CC=C3)=O
Molecular Formula
C17H17N3O3S
Molecular Weight
343.4
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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