Cytarabine 5′-monophosphate
Product Specifications
CAS Number
1890443
Target
Others|||Drug Metabolite|||DNA/RNA Synthesis
Related Pathways
Others|||DNA Damage/DNA Repair|||Cell Cycle/Checkpoint|||Metabolism
Bioactivity
Cytarabine 5?-monophosphate (ara-CMP), an active metabolite of the nucleoside analog cytarabine formed by deoxycytidine kinase, is incorporated into DNA by DNA polymerase ?, significantly slowing DNA synthesis. It inhibits nuclear and mitochondrial DNA replication in S. cerevisiae at 15 mM and improves survival in an L1210 murine leukemia model at 3.5-75.1 mg/kg.
Smiles
Nc1ccn([C@@H]2O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]2O)c(=O)n1
Molecular Formula
C9H14N3O8P
Molecular Weight
323.198
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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