PT-65
Product Specifications
CAS Number
2721998-87-2
Target
Others, GSK-3, PROTACs
Related Pathways
PI3K/Akt/mTOR signaling, Others, Stem Cells, PROTAC
Bioactivity
PT-65, a potent and selective GSK3 degrader, demonstrates the highest degradation capacity for GSK3α (DC50 = 28.3 nM) and GSK3β (DC50 = 34.2 nM) in SH-SY5Y cells, making it applicable for Alzheimer's disease research [1].
Smiles
O=C1C=2C(C(=O)N1C3C(=O)NC(=O)CC3)=CC=CC2NCCOCCOCCOCCOCCOCCN4C=C(CCCCN5CCN(S(=O)(=O)C6=CC=C(C=C6)C7=NC(C(NC=8C=CC=NC8)=O)=C(N)N=C7)CC5)N=N4
Molecular Formula
C51H63N13O12S
Molecular Weight
1082.19
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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