Trans-J-113863
Product Specifications
CAS Number
202796-42-7
Target
Others, CCR
Related Pathways
Others, Immunology/Inflammation, Microbiology/Virology, GPCR/G Protein
Bioactivity
Trans-J-113863 serves as a potent antagonist of chemokine receptors CCR1 and CCR3, effectively inhibiting MIP-1α-induced chemotaxis in CCR1 transfectants and eotaxin-induced chemotaxis in CCR3 transfectants, with respective half-maximal inhibitory concentrations (IC50) of 9.57 nM and 93.8 nM [1] [2].
Smiles
C(N[C@@H]1CC[N@+](CC=2CCCCCCC2)(CC)CC1)(=O)C3C=4C(OC=5C3=CC(Cl)=CC5)=CC=C(Cl)C4.[I-]
Molecular Formula
C30H37Cl2IN2O2
Molecular Weight
655.44
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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