PRT543
Product Specifications
CAS Number
1989620-03-2
Target
Others|||Histone Methyltransferase
Related Pathways
Chromatin/Epigenetic|||Others
Bioactivity
PRT543 is a potent selective inhibitor of the protein arginine methyltransferase 5 (PRMT5), showing a wide range of antitumor activities in vitro and in vivo. The compound also showed an inhibitory effect on methyltransferase activity of the PRMT5/MEP50 complex with an IC50 value of 10.8 nM.
Smiles
O[C@H]1[C@H](N2C=3C(C=C2)=C(N)N=CN3)O[C@]([C@H](O)C4=CC=C(Cl)C=C4)([C@H]1O)[H]
Molecular Formula
C17H17ClN4O4
Molecular Weight
376.79
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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