SOS1 agonist-1
Product Specifications
CAS Number
2245237-61-8
Target
Others, Ras
Related Pathways
MAPK, Others
Bioactivity
SOS1 agonist-1 (compound 79) serves as an agonist for the Son of sevenless homologue 1 (SOS1), a crucial guanine nucleotide exchange factor involved in catalyzing the GDP to GTP exchange on RAS proteins, thus regulating RAS activation. By increasing nucleotide exchange on RAS, SOS1 agonists enhance cellular RAS-GTP levels and induce biphasic signaling alterations in ERK1/2 phosphorylation, playing a pivotal role in anti-cancer activity [1].
Smiles
C(OC(C)(C)C)(=O)N1CC2(CN(C2)C=3N(CC4=CC(C)=C(F)C(C)=C4)C=5C(N3)=C(Br)C=C(Cl)C5)C1
Molecular Formula
C26H29BrClFN4O2
Molecular Weight
563.89
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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