HG-7-85-01-NH2
Product Specifications
CAS Number
1258391-29-5
Target
Ligands for Target Protein for PROTAC, Others, PROTACs, SNIPERs, Bcr-Abl
Related Pathways
Cytoskeletal Signaling, Angiogenesis, Others, Tyrosine Kinase/Adaptors, PROTAC
Bioactivity
HG-7-85-01-NH2, as the ligand for SNIPER (ABL) -033, effectively induces the reduction of BCR-ABL protein. This is achieved through SNIPER (ABL) -033, which connects HG-7-85-01 (an ABL inhibitor) to an LCL161 derivative (an IAP ligand) using a linker, demonstrating a DC50 value of 0.3 μM [1].
Smiles
C(C1=C(C(F)(F)F)C=C(NC(=O)C2=CC(=CC=C2)C=3N=C4C(=CC3)N=C(N)S4)C=C1)N5CCN(CC)CC5
Molecular Formula
C27H27F3N6OS
Molecular Weight
540.6
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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