(S) -Ro 32-0432
Product Specifications
CAS Number
1781828-85-0
Target
Others|||PKC
Related Pathways
Others|||Chromatin/Epigenetic|||Cytoskeletal Signaling
Bioactivity
(S) -Ro 32-0432 is a potent, selective inhibitor of protein kinase C (PKC) and G protein-coupled receptor kinase 5 (GRK5), demonstrating ATP-competitive and oral activity. It presents IC50 values of 9.3 nM for PKC?, 28 nM for PKC?I, 30 nM for PKC?II, 36.5 nM for PKC?, and 108.3 nM for PKC?, showcasing its effectiveness against multiple PKC isoforms. Additionally, (S) -Ro 32-0432 inhibits T-cell activation, indicating its potential application in the research of chronic inflammatory and autoimmune diseases [1] [2].
Smiles
O=C1C(C2=C3N(C=4C2=CC=CC4)CC[C@H](CN(C)C)C3)=C(C(=O)N1)C=5C=6C(N(C)C5)=CC=CC6.Cl
Molecular Formula
C28H29ClN4O2
Molecular Weight
489.01
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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