(S) -Ro 32-0432

(S) -Ro 32-0432 is a potent, selective inhibitor of protein kinase C (PKC) and G protein-coupled receptor kinase 5 (GRK5), demonstrating ATP-competitive and oral activity. It presents IC50 values of 9.3 nM for PKC?, 28 nM for PKC?I, 30 nM for PKC?II, 36.5 nM for PKC?, and 108.3 nM for PKC?, showcasing its effectiveness against multiple PKC isoforms. Additionally, (S) -Ro 32-0432 inhibits T-cell activation, indicating its potential application in the research of chronic inflammatory and autoimmune diseases [1] [2].