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CCR4 antagonist 4

Product Specifications

CAS Number

668980-17-4

Target

Others, CCR

Related Pathways

Others, Immunology/Inflammation, GPCR/G Protein, Microbiology/Virology

Bioactivity

CCR4 Antagonist 4 (Compound 22) is a potent and selective antagonist of the CC chemokine receptor-4 (CCR4), displaying an IC50 value of 0.02 μM. It also inhibits MDC-mediated chemotaxis and Ca2+ mobilization, with IC50 values of 0.007 μM and 0.003 μM, respectively. This compound is utilized in research on allergic inflammation [1].

Smiles

N(CC1=C(Cl)C=C(Cl)C=C1)C=2C3=C(N=C(N2)N4CCN(C(=O)[C@H]5CCCCN5)CC4)N=CC=C3

Molecular Formula

C24H27Cl2N7O

Molecular Weight

500.42

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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