KH-4-43
Product Specifications
CAS Number
2813310-07-3
Target
E1/E2/E3 Enzyme, Others
Related Pathways
Others, Ubiquitination
Bioactivity
KH-4-43, an inhibitor of the E3 CRL4 ligase complex, demonstrates anticancer activity by targeting the core of the E3 CRL4. It exhibits a binding affinity (Kd) of 83 nM to the E3 ROC1-CUL4A CTD and 9.4 μM to the closely related ROC1-CUL1 CTD [1].
Smiles
C(F)(F)(F)C1=C(C(=O)C=2C(O1)=C(O)C(O)=CC2)C3=CN(N=C3)C4=CC=C(Cl)C=C4
Molecular Formula
C19H10ClF3N2O4
Molecular Weight
422.74
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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