CAY10508
Product Specifications
CAS Number
878533-35-8
Target
Others, Cannabinoid Receptor
Related Pathways
Others, GPCR/G Protein
Bioactivity
CAY10508 is a potent and selective inverse agonist for the central cannabinoid (CB1) receptor with therapeutic potential for treating obesity and drug dependence, lacking psychotropic effects. It exhibits a Ki value of 243 nM and an EC50 of 195 nM. At a concentration of 10 μM, CAY10508 displaces [3H]-CP-55,940 with 100% efficacy at the CB1 receptor and 35% at the peripheral cannabinoid (CB2) receptor. Its inverse agonist activity at the CB1 receptor was confirmed through a [35S]-GTPγS binding assay.
Smiles
O=C1C(N(C(=O)N1C2=CC=C(Br)C=C2)C3=CC=C(Br)C=C3)C4=CC=CC=C4
Molecular Formula
C21H14Br2N2O2
Molecular Weight
486.2
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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